The Co-Evaluation of Ovarian Epithelium Edema and Congestion after the Erythropoietin effect on Ovarian Ischemia Reperfusion Injury

Aim: This study co-evaluated the 2 quoted histological variables after the erythropoietin (Epo) administration. The calculation was based on the results of 2 preliminary studies, each one evaluating a respective histological variable of ovarian epithelium edema (OE) or congestion (OC) in an induced ischemia reperfusion animal experiment. Materials and methods: The 2 main experimental endpoints at which the OE and OC scores were evaluated was the 60th reperfusion min (for the groups A and C)and the 120th reperfusion min (for the groups B and D). Specially, the groups A and B were processed without drugs, whereas the groups C and D after Epo administration. Results: The first preliminary study showed that Epo non significantly recessed the ovarian epithelium edema (OE) within the “without lesions alterations” grade by0.1272727 [-0.4530022 - +0.1984567](pvalue=0.4339)1. However, the second preliminary study showed that Eponon significantly enhanced the ovarian congestion (OC) within the “without lesions alterations” grade by0.1454545 [-0.1918887 - +0.4827978](p-value=0.3882)2. These 2 studies were co-evaluated since they came from the same experimental setting. This study investigated the combined diagnostic value of both variables together. Conclusions: Epo has a hardly deteriorating potency of these histologic parameters within the “without lesions alterations” grade by 0.0090909 [-0.2586031 -+0.2767849] (p-value=0.9456) since they were coevaluated together.

Keywords: ischemia, ovarian epitheliumedema, congestion, erythropoietin, reperfusion.