Understanding Collagen Supplements in Arthritis - Immunomodulation with Undenatured Collagen II Versus Cartilage Building with Hydrolysed Collagen II

Rheumatoid Arthritis is known to have a T cell mediated autoimmune aetiology causing joint cartilage destruction. Osteoarthritis, though regarded as a degenerative disease, also shows a T cell immune response and inflammatory cartilage damage. Both types of Arthritis at a cellular level show T helper cell activation, involvement of pro-inflammatory cytokines and increased destruction of cartilage by Matrix Metalloproteinase enzymes. There is also evidence of relative suppression of anti-inflammatory cytokines and T regulatory cells which can perpetuate the cartilage loss. Supplementing hydrolysed Collagen type II to aid the body rebuild joint cartilage in the scenario of continuous cartilage destruction may not give the desired results. Therefore, reduction of inflammatory cartilage damage through the mechanism of specific immunomodulation by preventing immune response against collagen type II in joint cartilage, appears to be a scientifically rational option in both Rheumatoid Arthritis and Osteoarthritis.

Keywords: Rheumatoid Arthritis, Osteoarthritis, Cartilage, Undenatured Collagen Type II, T cell, autoimmune, immunomodulation, Matrix Metalloproteinase, Cytokines.