The Role of Genetics Mutations in Genes EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5 in induce Leukoencephalopathy with Vanishing White Matter Syndrome

LVWM syndrome is a progressive genetic disorder that affects the brain and spinal cord (central nervous system). In most cases, people with LVWM syndrome do not reveal any symptoms of birth defects. Children with this syndrome delay the development of motor skills such as sitting and walking. The LVWM syndrome is based on the mutation of the EIF2B1 gene, which is based on 12q24.31 in the long arm of chromosome 12, and the EIF2B2 gene, which is located in the long arm of Chromosome 14, which is 14q24.3, has the EIF2B3 gene in the short arm of chromosome 1 of 1p34. 1, the EIF2B4 gene, which is based on the short arm of chromosome number 2, is positioned as 2p23.3, and the EIF2B5 gene, which is based on the long arm of chromosome number 3, is based on 3q27.1.

Keywords: LVWM syndrome, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5 genes, Brain disorders.