Optimization Effect of Superdisintegrants and Subliming Agent on Orodispersible Tablet of Loratidine

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Shivani Mehta, Dr. Shridhar Pandya

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Published: 18 June 2020 | Article Type :

Abstract

Loratidine is an anti-histamine drug. Bitter taste of the Loratidine is a problem in ensuring patient compliance. Resinates of Loratidine were prepared with Indion 234 and loading process was optimized. A 3² factorial design was used for formulation development of orodispersible tablet of these taste masked resinates. The amount of subliming agent (camphor) and superdisintegrants (sodium starch glycolate) were taken as formulation variables (factors) for optimizing disintegration time, drug release after 15 minutes and friability as dependent or response variables. A mathematical model was generated for each response parameter. The disintegration time was found to linearly increase with the increase in the amount of superdisintegrants. The percentage friability showed no definite relationship with either amount of subliming agent or superdisintegrants. The optimum formulations were chosen by grid search method and their predicted results were found to be in close agreement with experimental findings.

Keywords: oral disintegrating tablets, Loratidine, factorial design, contour plots, response surface methodology

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Shivani Mehta, Dr. Shridhar Pandya. (2020-06-18). "Optimization Effect of Superdisintegrants and Subliming Agent on Orodispersible Tablet of Loratidine." *Volume 3*, 1, 1-5