Preparation and Evaluation of Nimesulide Loaded Nanoparticles by Nanoprecipitation Technique

Nimesulide loaded nanoparticles were prepared by nanoprecipitation technique. Ethyl cellulose was chosen as a polymer. The obtained nanoparticles were evaluated for product yield, drug content, and entrapment efficiency and loading capacity. The product yield, drug content, entrapment efficiency and loading capacity were observed to be 80.5%, 60.7%, 38.2% and 9.9% respectively. The SEM image clearly indicates the nanoparticles.