Corneal Alterations in Subjects with Downs Syndrome and Celiac Disease

Aim: To assess the presence of changes in corneal thickness in. the patients with Down’s syndrome (DS) and celiac disease (CD)
Materials and Methods: Fortyeight subjects with Down’s syndrome ( 23 men and 24 women) were enrolled in the study.22 subjects were suffered from celiac disease too .

Results: 4 subjects ( 8.5%) , including 3 with CD, presented keratoconus at stage 1 or 2 according to the Amsler-Krumeich classification.
The pachymetric examination in subjects with celiac disease showed in 12( 54,5%) a corneal thickness at the lower limit of the relevant range for the respective age groups. and in 10 (45,5) a pathological thickness.
In subjects with only DS the corneal thickness was at the lower limit of the relevant range in 18(72%)

Conclusion: Subjects with DS and celiac disease too present a reduced corneal thickness and a higher frequency of keratoconus.

Keywords: Down’s syndrome; Celiac disease; Corneal thickness; Keratoconus.