Laser and Ultrasound Activated Photolon Nanocomposite in Tumor-Bearing Mice: New Cancer Fighting Drug-Technique

This study was directed at study the effectiveness of cancer targeted therapy using the activated photolon nanocomposite (Nano-PhLon). Study was applied on male Swiss albino mice, implanted with Ehrlich tumor (EAC) divided into six groups. Two energy sources were used; laser and Ultrasound. Results showed that Nano-PhLon is a potential sensitizer for photodynamic or sonodynamic treatment of tumor. Nano-PhLon plays an important role in tumor growth inhibition and cell death induction. Activated Nano-PhLon with both infrared laser and ultrasound has a potential antitumor effect. The results indicated that (FA–NGO–PhLon) could be used as a unique nanocomposite for cancer targeted therapy SPDT.

Keywords: implanted tumor; Nano-photolon; sonodynamic therapy; photodynamic therapy.