Accelerated Atherosclerosis in the Setting of Chronic Kidney Disease

Author Details

Allison B. Reiss, Amy D. Glass, Heather A. Renna, David J. Grossfeld, Daniel S. Glass, Lora J. Kasselman, Joshua De Leon

Journal Details

Published

Published: 2 March 2019 | Article Type :

Abstract

Between 35% and 50% of deaths among patients with chronic kidney disease (CKD) can be attributed to cardiovascular disease. Even after adjusting for traditional cardiovascular risk factors, cardiovascular mortality risk is substantially increased in a linear fashion with decreasing glomerular filtration rate in CKD. Uremic toxins, oxidative stress and inflammation are critical factors found in CKD that can accelerate the atherosclerotic process. Although the precise mechanistic link(s) between CKD and cardiovascular disease are not yet fully defined, this review will discuss the current state of our knowledge. Lack of effective treatment for cardiovascular disease in CKD is a major unmet clinical need that can only be resolved with greater insight into the unique molecular and cellular mechanisms underlying cardiovacular disease pathogenesis in CKD.

Keywords: Atherosclerosis, Ckd, Statin, Inflammation, Oxidative Stress, Microbiome.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Copyright © Author(s) retain the copyright of this article.

Statistics

279 Views

442 Downloads

Volume & Issue

Article Type

How to Cite

Citation:

Allison B. Reiss, Amy D. Glass, Heather A. Renna, David J. Grossfeld, Daniel S. Glass, Lora J. Kasselman, Joshua De Leon. (2019-03-02). "Accelerated Atherosclerosis in the Setting of Chronic Kidney Disease." *Volume 2*, 1, 6-14