False Positive Syphilis Serology after IVIG Administration

Author Details

Kaur, Kamalmeet, Sohal, Aalam, Sandhu, Sunny, Kelley, William

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Published: 5 July 2021 | Article Type :


We report a case of a 44 year old female with Systemic Lupus Erythematosus (SLE) who received intravenous immunoglobulin (IVIG) and was subsequently found to have positive Immunoglobulin G (IgG) syphilis serology. The chronology of the positive serologies, with documented testing prior to IVIG administration being negative, suggests that the tests represent a false positive result secondary to the passive transfer of the immunoglobulin component. While the phenomenon of multiple positive serologies in a short time span after IVIG administration has been described, it is rarely recognized, and poses risks to the patient through unnecessary treatment.

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Kaur, Kamalmeet, Sohal, Aalam, Sandhu, Sunny, Kelley, William. (2021-07-05). "False Positive Syphilis Serology after IVIG Administration." *Volume 4*, 1, 1-3