Introduction: Staphylococcus aureus is one of the most important pathogens causing various forms of infection and is a major nosocomial infection agent. In recent years, due to the inappropriate use of antibiotics, drug resistance among microorganisms, including Staphylococcus aureus has increased. This study was conducted to determine the antibiotic resistance pattern of staphylococcus aureus spices isolated from patients referring to Shahid Sadoughi Hospital in Yazd during 2017-2018.
Materials and Methods: For this descriptive-analytic study, all positive cultures of Staphylococcus aureus in patients referred to Shahid Sadoughi Hospital in Yazd during 2017-2018 were evaluated. The samples included blood culture, urine culture, wound discharge culture, throat culture, peritoneal culture, pleural culture, synovial culture, CSF culture, bronchial lavage culture. Antibiotic resistance patterns of the samples against 13 different antibiotics were determined by the standard method of Disc Diffusion and data analyzed by SPSS 22 software.
Results: The highest antibiotics resistance was seen against Penicillin (92.4%), Tetracycline (52%), Erythromycin (50%), Cefoxitin (40.5%), Doxycycline (36.4%), Ciprofloxacin (34.3%), Clindamycin (33.6%), Cotrimaxazole (25.3%) and the lowest resistance levels were against gentamycin (18.6%).
Conclusion: The result of this study similar to the result of other studies shows the high prevalence of drug resistance among Staphylococcus aureus strains that is caused by inappropriate administration of antibiotics. The high sensitivity of Linezolid and Vancomycin shows important role of these antibiotics in treatment of resistance cases.
Keywords: Staphylococcus aureus; Antibiotics; Drug resistance.